Just as the content of your web site has to be optimized to appeal to both Google and the human visitor, the design of your site has two competing goals. It also has to appeal to the human visitor, presenting your quality content in a form that engages your visitor and keeps them on your site. But you also want the vistor leave your web site by clicking on one or more of the adverts or affilates that earn you money. Just as with the content, the secret is balance. You can have an affliate friendly and search engine friendly web site design at the same time.
To do this, you employ the same principle all business's have to use: Give the customer what they want. To work out what this is, pay attention to your own search habits.
Think about these thing and make sure that your own web site isn't below the quality you expect from other peoples.
Most of affiliate and SEO web site design is commonsense. The newly arrived visitor will want to quickly to find whatever it is they are looking for. So use a clear, readable color scheme with a reasonable sized fonts for your text. Especially your page headings and sub-headings. Lots of visitors will quickly scan down the page looking at the section headings and only read in detail when something catches their eye.
In SEO friendly web design you must consider how you use your keywords in your headings, the best place for adverts on a web page and all the other factors that effect your position in Google's rankings. Work your through the SEO checklist.
Chris Tregenza runs a variety of web sites including MiceLife, writes free seo articles and a SEO Blog
Better search engine placement through article writing.